The clinical response to infliximab in rheumatoid arthritis is in part dependent on pre-treatment TNFα expression in the synovium
نویسندگان
چکیده
1 Division of Clinical Immunology and Rheumatology, and 2 Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center/ University of Amsterdam, Amsterdam, the Netherlands. 3 Jan van Breemen Institute, Amsterdam, The Netherlands. 4 Department of Rheumatology, Slotervaart Hospital, Amsterdam, The Netherlands. VU Medical Center, Amsterdam, The Netherlands. * Present address Schering Plough Research Institute.
منابع مشابه
The clinical response to infliximab in rheumatoid arthritis is in part dependent on pretreatment tumour necrosis factor α expression in the synovium
OBJECTIVE To determine whether the heterogeneous clinical response to tumour necrosis factor (TNF)alpha blocking therapy in rheumatoid arthritis (RA) can be predicted by TNFalpha expression in the synovium before initiation of treatment. METHODS Prior to initiation of infliximab treatment, arthroscopic synovial tissue biopsies were obtained from 143 patients with active RA. At week 16, clinic...
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تاریخ انتشار 2007